Cell biology of herpes viruses
Preface -- References -- Contents -- Chapter 1: Initial Contact: The First Steps in Herpesvirus Entry -- 1.1 Introduction -- 1.2 Attachment to Cells -- 1.3 Receptor Binding -- 1.3.1 gD-Binding Receptors -- 1.3.1.1 Herpes Simplex Viruses -- 1.3.1.2 Equine Herpesviruses -- 1.3.2 gB-Binding Receptors -...
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| Format: | UnknownFormat |
| Sprache: | eng |
| Veröffentlicht: |
Berlin u.a
Springer
2017
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| Ausgabe: | 1st ed. 2017 |
| Schriftenreihe: | Advances in anatomy, embryology and cell biology
223 |
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| Online Zugang: | Inhaltstext http://www.springer.com/ |
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Tag hinzufügen | Zusammenfassung: | Preface -- References -- Contents -- Chapter 1: Initial Contact: The First Steps in Herpesvirus Entry -- 1.1 Introduction -- 1.2 Attachment to Cells -- 1.3 Receptor Binding -- 1.3.1 gD-Binding Receptors -- 1.3.1.1 Herpes Simplex Viruses -- 1.3.1.2 Equine Herpesviruses -- 1.3.2 gB-Binding Receptors -- 1.3.3 gH/gL-Binding Receptors -- 1.3.4 gE-Binding Receptors -- 1.4 Signaling Triggered by Alphaherpesvirus Binding to Cellular Receptors -- 1.5 Calcium-Signaling Pathways -- 1.6 Small GTPases -- 1.7 Model of Entry: Refinement -- 1.8 Conclusion and Remarks -- References -- Chapter 2: Herpes simplex virus Membrane Fusion -- 2.1 Introduction -- 2.2 Types of Fusion Mediated by HSV Glycoproteins -- 2.2.1 Virus-Cell Fusion During Entry -- 2.2.2 Fusion of Primary Enveloped HSV-1 with the Outer Nuclear Membrane -- 2.2.3 HSV Syncytium Formation -- 2.2.4 Fusion from Without -- 2.2.5 Transfected Cell Fusion -- 2.3 Summary and Future Directions -- References -- Chapter 3: Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease -- 3.1 Introduction -- 3.1.1 Pattern Recognition Receptors, Signaling, and Effector Pathways -- 3.2 Sensing and Signaling Pathways -- 3.2.1 Sensing of Virion and Infected Cell Proteins -- 3.2.2 Sensing of HSV DNA -- 3.2.3 PYHIN (PYRIN and HIN Domain) Family Proteins -- 3.2.4 Sensing of HSV RNA -- 3.2.5 Sensing of Viral Fusion -- 3.3 Cellular Effector Mechanisms -- 3.4 Viral Evasion -- 3.5 Mechanisms in Animal Models -- 3.6 Manifestations in Humans -- 3.6.1 Perspective -- References -- Chapter 4: The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies -- 4.1 Introduction -- 4.2 PML-NBs and Intrinsic Immunity -- 4.2.1 Architecture of PML-NBs -- 4.2.2 Repression of HCMV Transcription by PML-NB Components -- 4.3 PML-NBs as Co-regulatory Structures of Innate Immune Responses 4.4 IE1 as an Antagonist of Intrinsic and Innate Immune Responses -- 4.4.1 Expression and Importance of IE1 During Lytic Infection -- 4.4.2 Structure of IE1 -- 4.4.3 Molecular Mechanism of IE1-Mediated PML-NB Antagonization -- 4.5 Summary and Outlook -- References -- Chapter 5: Herpesvirus Latency: On the Importance of Positioning Oneself -- 5.1 Introduction -- 5.2 Interaction Between Latent Viral Genomes and Chromosomal Regions -- 5.2.1 Integration in the Host Cell Genome -- 5.2.2 Chromosome Anchoring -- 5.2.3 Centromere/Pericentromere Deposition -- 5.3 Viral Genomes and PML-NBs: Janus-Faced Nuclear Bodies -- 5.4 PML-NB Entrapment of HSV-1 Genomes During Latency/Quiescence -- 5.5 Conclusion -- References -- Chapter 6: Herpesvirus Capsid Assembly and DNA Packaging -- 6.1 The Herpesvirus Virion -- 6.2 Capsid Assembly -- 6.3 DNA Packaging -- 6.4 Model of HSV DNA Packaging -- 6.5 Conclusions and Outlook -- References -- Chapter 7: Herpesvirus Nuclear Egress -- 7.1 Overview of the Nuclear Egress Process -- 7.2 The Nuclear Egress Complex (NEC) -- 7.3 Interaction of pUL31 and pUL34 and Localization of the Nuclear Egress Complex -- 7.4 Changes in Overall Nuclear Architecture -- 7.5 Structure and Alteration of the Nuclear Lamina Induced by Herpesviruses -- 7.6 Formation of the Envelopment Substrate: DNA-Containing Capsids -- 7.7 Capsid Recruitment to the Nuclear Membrane -- 7.8 Capsid Docking -- 7.9 Budding -- 7.10 Regulation of Budding -- 7.11 Uncoating and De-envelopment -- 7.12 Later Events -- Bibliography -- Chapter 8: Assembly and Egress of an Alphaherpesvirus Clockwork -- 8.1 Introduction -- 8.2 The Herpesvirus Virion -- 8.3 The Virion Clockwork -- 8.4 Assembly of a Postentry Trigger -- 8.5 Assembly of a Cell-Surface Trigger -- 8.6 Delivery -- 8.7 Summary and Outlook -- References -- Chapter 9: Interindividual Spread of Herpesviruses 9.1 Introduction -- 9.2 Interindividual Spread in Nature -- 9.3 Interspecies Spread in Nature -- 9.4 Animal Models -- 9.5 Marek´s Disease Pathogenesis and MDV Replication -- 9.5.1 Interindividual Spread-Deficient MDV -- 9.6 Alphaherpesvirus gC Homologues -- 9.6.1 The Complement System and Its Subversion by Viruses -- 9.6.2 MDV gC -- 9.6.2.1 Potential Role(s) for MDV gC in Transmission -- Immune Evasion -- Attachment/Receptor Binding -- Immune Factor-Mediated (Trojan Horse) Receptor Binding/Opsonization -- Summary -- 9.7 Conserved Herpesviral Protein Kinases -- 9.7.1 MDV CHPK (UL13) -- 9.7.1.1 Potential Role(s) for MDV UL13 in Transmission -- Virus Assembly in FFE Cells -- Evasion of the Interferon Response -- Virus Entry into B Cells and/or Macrophages in the Lung -- Summary -- 9.8 Conclusions -- References |
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| Beschreibung: | X, 215 Seiten in 1 Teil 20 Illustrationen 23.5 cm x 15.5 cm, 0 g |
| ISBN: | 3319531670 3-319-53167-0 9783319531670 978-3-319-53167-0 |