Coronaviruses
Front Cover -- Coronaviruses -- Copyright -- In Memoriam -- Contents -- Contributors -- Preface -- Chapter One: Supramolecular Architecture of the Coronavirus Particle -- 1. Introduction -- 2. Virion Structure and Durability -- 3. Viral Proteins in Assembly and Fusion -- 3.1. Membrane Protein -- 3.2...
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| Format: | UnknownFormat |
| Sprache: | eng |
| Veröffentlicht: |
Amsterdam u. a.
Elsevier, Acad. Press
2016
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| Ausgabe: | First edition |
| Schriftenreihe: | Advances in virus research
96.2016 |
| Schlagworte: | |
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Tag hinzufügen | Zusammenfassung: | Front Cover -- Coronaviruses -- Copyright -- In Memoriam -- Contents -- Contributors -- Preface -- Chapter One: Supramolecular Architecture of the Coronavirus Particle -- 1. Introduction -- 2. Virion Structure and Durability -- 3. Viral Proteins in Assembly and Fusion -- 3.1. Membrane Protein -- 3.2. Nucleoprotein -- 3.3. Envelope Protein -- 3.4. Spike Protein -- 4. Evolution of the Structural Proteins -- References -- Chapter Two: Coronavirus Spike Protein and Tropism Changes -- 1. Introduction -- 2. Structure of the Coronavirus S Protein -- 2.1. Structure of the S1 Subunit 2.2. Structure of the S2 Subunit -- 3. Spike-Receptor Interactions -- 3.1. Different Domains Within S1 May Act as RBD -- 3.2. CoV Protein Receptor Preference -- 4. S Protein Proteolytic Cleavage and Conformational Changes -- 5. Tropism Changes Associated with S Protein Mutations -- 5.1. S1 Receptor Interactions Determining Tropism -- 5.1.1. S1 NTR Changes -- 5.1.2. S1 CTR Changes -- 5.2. Changes in Proteolytic Cleavage Site and Other S2 Mutations Associated with Altered Tropism -- 5.2.1. Changes in Proteolytic Cleavage Sites -- 5.2.2. Other S2 Mutations Associated with Altered Tropism 6. Concluding Remarks -- Acknowledgments -- References -- Chapter Three: The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing -- 1. Introduction -- 2. Coronavirus nsp7-10: Small but Critical Regulatory Subunits? -- 2.1. Coronavirus nsp7 -- 2.2. Coronavirus nsp8 and nsp7-nsp8 Complexes -- 2.3. Coronavirus nsp9 -- 2.4. Coronavirus nsp10 -- 3. Coronavirus nsp12: A Multidomain RNA Polymerase -- 3.1. The nsp12 RdRp Domain -- 3.2. The Initiation Mechanism of the nsp12 RdRp -- 3.3. Inhibitors of the nsp12 RdRp -- 3.4. The nsp12 NiRAN Domain 4. Coronavirus nsp13: A Multifunctional and Highly Conserved Helicase Subunit -- 4.1. The Coronavirus nsp13 SF1 Helicase (HEL1) -- 4.2. The Helicase-Associated ZBD -- 4.3. Nidovirus Helicase Structural Biology -- 4.4. Functional Characterization of the Nidovirus Helicase -- 4.5. The Coronavirus Helicase as Drug Target -- 5. The Coronavirus Capping Machinery: nsp10-13-14-16 -- 5.1. The nsp13 RNA 5' Triphosphatase -- 5.2. The Elusive RNA GTase -- 5.3. The nsp14 N7-Methyl Transferase -- 5.4. The nsp16 2'-O-Methyl Transferase 6. Coronavirus nsp14 ExoN: Key to a Unique Mismatch Repair Mechanism That Promotes Fidelity -- 7. Coronavirus nsp15: A Remarkable Endoribonuclease with Elusive Functions -- 8. Summary and Future Perspectives -- Acknowledgments -- References -- Chapter Four: Coronavirus cis-Acting RNA Elements -- 1. Introduction -- 2. Coronavirus Genome Replication and Transcription -- 3. Coronavirus cis-Acting RNA Elements -- 3.1. 5-Terminal cis-Acting RNA Elements -- 3.1.1. Structural Features of Coronavirus 5'-Terminal cis-Acting Elements -- 3.1.2. Functional Roles of Coronavirus 5'-Terminal cis-Acting Elements 3.1.2.1. Stem-Loops 1 and 2 |
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| Beschreibung: | xiv, 295 Seiten |
| ISBN: | 9780128047361 |