Molecular and cellular basis of metastasis road to therapy
Chapter One: Detecting Tumor Metastases: The Road to Therapy Starts Here -- 1. Introduction -- 2. Preclinical In Vitro and In Vivo Models of Metastasis -- 2.1. In Vitro Models -- 2.2. In Vivo Models -- 3. Approaches Currently Used to Detect Metastatic Lesions (on a Preclinical Level) -- 3.1. Lab Tes...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | UnknownFormat |
| Sprache: | eng |
| Veröffentlicht: |
Amsterdam, Boston, Heidelberg und 9 andere
Elsevier, Academic Press
2016
|
| Ausgabe: | First edition |
| Schriftenreihe: | Advances in cancer research
volume 132 |
| Schlagworte: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Tag hinzufügen | Zusammenfassung: | Chapter One: Detecting Tumor Metastases: The Road to Therapy Starts Here -- 1. Introduction -- 2. Preclinical In Vitro and In Vivo Models of Metastasis -- 2.1. In Vitro Models -- 2.2. In Vivo Models -- 3. Approaches Currently Used to Detect Metastatic Lesions (on a Preclinical Level) -- 3.1. Lab Tests/Histopathology -- 3.2. Noninvasive Blood Tests -- 3.3. Small Animal Imaging -- 3.4. Molecular-Genetic Imaging (Promoter-Based Protocols) -- 3.5. Circulating Tumor Cells -- 4. Approaches Used to Detect Metastatic Lesions (on a Clinical Level) -- 4.1. Biomarkers for Metastasis -- 4.2. Imaging Procedures -- 4.3. Circulating Tumor Cells -- 5. Metastasis Detection/Therapy: Combining Imaging with Therapy (Theranostics) -- 6. Challenges Faced in Detecting Metastatic Cells -- 7. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Two: The Relationship Between Dormant Cancer Cells and Their Microenvironment -- 1. Introduction -- 2. Models to Study Tumor Cell Dormancy -- 3. Intrinsic and Extrinsic Signals Converge to Induce Tumor Cell Dormancy -- 4. Cooperative Extrinsic Signals Induce Dormancy Within the Bone Microenvironment -- 5. Endosteal and Perivascular Niches Support Cancer Cell Dormancy -- 6. Reactivation from Dormancy -- 7. The Immune System and Dormancy -- 8. Summary and Outlook -- References -- Chapter Three: Defining the Influence of Germline Variation on Metastasis Using Systems Genetics Approaches -- 1. Introduction -- 2. Hereditary Factors Associated with Cancer Aggressiveness and Metastasis in Human Populations -- 2.1. Epidemiological Analysis -- 2.2. Genetic Analysis Human Cohorts -- 3. Systems Genetics Approaches to Identify Hereditary Modifiers of Metastasis -- 3.1. Breast Cancer -- 3.2. Prostate Cancer -- 3.3. Melanoma -- 4. Conclusions -- Acknowledgments -- References -- Chapter Four: Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic ... -- Concluding Thoughts -- Acknowledgments -- References -- Chapter Five: Immune Regulation of the Metastatic Process: Implications for Therapy -- 1. Introduction -- 2. Key Players -- 2.1. Monocytes -- 2.2. Macrophages -- 2.3. Neutrophils -- 2.4. T Lymphocytes -- 2.5. Natural Killer Cells -- 3. Invasion and Intravasation -- 3.1. Macrophages -- 3.2. Neutrophils -- 3.3. T Lymphocytes -- 4. Survival and Extravasation -- 4.1. Monocytes -- 4.2. Neutrophils -- 4.3. T Lymphocytes -- 4.4. NK Cells -- 5. Ectopic Growth -- 5.1. Macrophages -- 5.2. Neutrophils -- 5.3. T Lymphocytes -- 5.4. NK Cells -- 6. Therapeutic Implications -- Acknowledgments -- References -- Chapter Six: MicroRNA and Metastasis -- 1. MicroRNAs -- 1.1. Noncoding RNAs and the Discovery of MicroRNAs -- 1.2. miRNA Biogenesis and Mechanisms of Action -- 1.3. miRNA Functions -- 2. miRNAs in Cancer ... |
|---|---|
| Beschreibung: | xiv, 376 Seiten Illustrationen |
| ISBN: | 9780128041406 978-0-12-804140-6 |