Pharmacology of G protein coupled receptors
Use of GPCR structures in drug design -- Allosteric modulation of metabotropic glutamate receptors -- Refining efficacy: exploiting functional selectivity for drug discovery -- Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptors -- Regulation of stability and traffickin...
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| Format: | UnknownFormat |
| Sprache: | eng |
| Veröffentlicht: |
Amsterdam u.a.
Elsevier, Academic Press
2011
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| Ausgabe: | 1. ed. |
| Schriftenreihe: | Advances in pharmacology
62 |
| Schlagworte: | |
| Online Zugang: | Inhaltsverzeichnis |
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Tag hinzufügen | Zusammenfassung: | Use of GPCR structures in drug design -- Allosteric modulation of metabotropic glutamate receptors -- Refining efficacy: exploiting functional selectivity for drug discovery -- Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptors -- Regulation of stability and trafficking of calcium-sensing receptors by pharmacologic chaperones -- Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors -- Biological and pharmacological roles of HCA receptors -- Pharmacology, signaling and physiological relevance of the G protein-coupled receptor 55 -- Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity -- Regulator of G protein signaling proteins as drug targets: current state and future possibilities -- GPCR-interacting proteins, major players of GPCR function. |
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| Beschreibung: | Literaturangaben |
| Beschreibung: | XVI, 391 S. Ill., graph. Darst. |
| ISBN: | 9780123859525 978-0-12-385952-5 |