Adaptive and flexible clinical trials

1. Background -- 2. Conventional statistics -- 3. Statistics used in adaptive clinical trials -- 4. Specific requirements for adaptive trials -- 5. Adaptive randomization and allocation -- 6. Sample size reestimation -- 7. Traditional dosing -- 8. Adaptive dosing -- 9. Interim analysis and adaptive...

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1. Verfasser:	Chin, Richard (VerfasserIn)
Format:	UnknownFormat
Sprache:	eng
Veröffentlicht:	Boca Raton, Fla. u.a. CRC Press, Taylor & Francis c2012
Schlagworte:	Clinical trials > Clinical Trials as Topic > Database Management Systems > trends > Efficiency, Organizational > Research Design > Klinische Prüfung > Klinisches Experiment
Online Zugang:	Inhaltsverzeichnis Inhaltstext
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Beschreibung
Zusammenfassung:	1. Background -- 2. Conventional statistics -- 3. Statistics used in adaptive clinical trials -- 4. Specific requirements for adaptive trials -- 5. Adaptive randomization and allocation -- 6. Sample size reestimation -- 7. Traditional dosing -- 8. Adaptive dosing -- 9. Interim analysis and adaptive termination of study and study arms -- 10. Adaptive changes in study design and decision rules -- 11. Seamless designs and adaptive clinical trial conduct -- 12. Analysis and interpretation of results.
Beschreibung:	Formerly CIP Uk. - Includes bibliographical references and index
Beschreibung:	XIII, 184 S. graph. Darst. 24 cm
ISBN:	1439838321 1-4398-3832-1 9781439838327 978-1-4398-3832-7