Aquaporins
Discovery of the aquaporins and development of the field -- Aquaporin protein structure and selectivity mechanisms -- AQP structure and functional implications -- Dynamics and energetics of permeation through aquaporins. What do we learn from molecular dynamics simulations? -- In vitro analysis and...
Gespeichert in:
| Weitere Verfasser: | , |
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| Format: | UnknownFormat |
| Sprache: | eng |
| Veröffentlicht: |
Berlin u.a.
Springer
2009
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| Schriftenreihe: | Handbook of experimental pharmacology
190 |
| Schlagworte: | |
| Online Zugang: | Inhaltsverzeichnis |
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Tag hinzufügen | Zusammenfassung: | Discovery of the aquaporins and development of the field -- Aquaporin protein structure and selectivity mechanisms -- AQP structure and functional implications -- Dynamics and energetics of permeation through aquaporins. What do we learn from molecular dynamics simulations? -- In vitro analysis and modification of aquaporin pore selectivity -- Aquaporin function in mammalian water homeostasis -- Aquaporins in the kidney -- Regulation of aquaporin-2 trafficking -- Role of aquaporin-4 in cerebral edema and stroke -- Aquaporins as potential drug targets for Meniere's disease and its related diseases -- Aquaporins in secretory glands and their role in Sjögren's syndrome -- Aquaporin gylcerol permeability in mammalian physiology -- Skin aquaporins: function in hydration, wound healing, and skin epidermis homeostasis -- Function of aquaporin-7 in the kidney and the male reproductive system -- Role of aquaporin-7 and aquaporin-9 in glycerol metabolism; involvement in obesity -- New members of mammalian aquaporins: AQP10-AQP12 -- Aquaporin functions apart from water and glycerol transport -- Structural function of MIP/aquaporin 0 in the eye lens; genetic defects lead to congenital inherited cataracts -- pH regulated anion permeability of aquaporin-6 -- Aquaglyceroporins and metalloid transport: implications in human diseases -- Ammonia and urea permeability of mammalian aquaporins -- Knock-out models reveal new aquaporin functions -- Towards therapeutic use of aquaporins -- Design, synthesis and assaying of potential aquaporin inhibitors -- Aquaporin-1 gene transfer to correct radiation-induced salivary hypofunction. |
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| Beschreibung: | Literaturangaben |
| Beschreibung: | XVI, 424 S. Ill., graph. Darst. |
| ISBN: | 9783540798842 978-3-540-79884-2 |