Modular DNA constructs for oligovalent bio-enhancement and functional screening

Dissertation, Universität Potsdam, 2021

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Bibliographische Detailangaben
1. Verfasser:	Möser, Christin (VerfasserIn)
Körperschaft:	Universität Potsdam (Grad-verleihende Institution)
Weitere Verfasser:	Bier, Frank (AkademischeR BetreuerIn), Bald, Ilko (AkademischeR BetreuerIn), Fritzsche, Wolfgang (AkademischeR BetreuerIn), Smith, David M. (AkademischeR BetreuerIn)
Format:	UnknownFormat
Sprache:	eng
Veröffentlicht:	Potsdam 2021
Schlagworte:	Hochschulschrift > DNS > Nanostruktur > Funktionelle Gruppe > DNS-Origami > Epitop > Antikörper > Chemische Bindung
Online Zugang:	Inhaltsverzeichnis
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Beschreibung
Zusammenfassung:	Dissertation, Universität Potsdam, 2021 Deoxyribonucleic acid (DNA) nanostructures enable the attachment of functional molecules to nearly any unique location on their underlying structure. Due to their single-base-pair structural resolution, several ligands can be spatially arranged and closely controlled according to the geometry of their desired target, resulting in optimized binding and/or signaling interactions. This dissertation covers three main projects. All of them use variations of functionalized DNA nanostructures that act as platform for oligovalent presentation of ligands. The purpose of this work was to evaluate the ability of DNA nanostructures to precisely display different types of functional molecules and to consequently enhance their efficacy according to the concept of multivalency. Moreover, functionalized DNA structures were examined for their suitability in functional screening assays. The developed DNA-based compound ligands were used to target structures in different biological systems. One part of this dissertation attempted to bind pathogens ...
Beschreibung:	XIV, 148 Seiten Illustrationen, Diagramme