Trace element effects on longevity and neurodegeneration with focus on C. elegans

Dissertation, Universität Potsdam, 2021

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Bibliographische Detailangaben
1. Verfasser:	Baesler, Jessica (VerfasserIn)
Körperschaft:	Universität Potsdam (Grad-verleihende Institution)
Weitere Verfasser:	Schwerdtle, Tanja (AkademischeR BetreuerIn), Kipp, Anna Patricia (AkademischeR BetreuerIn), Michalke, Bernhard (AkademischeR BetreuerIn)
Format:	UnknownFormat
Sprache:	eng
Veröffentlicht:	Potsdam 2021
Schlagworte:	Hochschulschrift > Caenorhabditis elegans > Nervendegeneration > Exposition > Spurenelement
Online Zugang:	Inhaltsverzeichnis
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Beschreibung
Zusammenfassung:	Dissertation, Universität Potsdam, 2021 The trace elements zinc and manganese are essential for human health, especially due to their enzymatic and protein stabilizing functions. If these elements are ingested in amounts exceeding the requirements, regulatory processes for maintaining their physiological concentrations (homeostasis) can be disturbed. Those homeostatic dysregulations can cause severe health effects including the emergence of neurodegenerative disorders such as Parkinson’s disease (PD). The concentrations of essential trace elements also change during the aging process. However, the relations of cause and consequence between increased manganese and zinc uptake and its influence on the aging process and the emergence of the aging-associated PD are still rarely understood. This doctoral thesis therefore aimed to investigate the influence of a nutritive zinc and/or manganese oversupply on the metal homeostasis during the aging process. For that, the model organism Caenorhabditis elegans (C. elegans) was applied. [...]
Beschreibung:	Übersetzung des Haupttitels: Effekte von Spurenelementen auf die Lebensdauer und Neurodegeneration mit Fokus auf C. elegans Kumulative Dissertation
Beschreibung:	X,114,viii Seiten Illustrationen, Diagramme