Charakterisierung zellautonomer Selbstverteidigung und pathogenvermittelter Gegenwehr in Coxiella burnetii-infizierten dendritischen Zellen und natürlichen Killerzellen

Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2021

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Bibliographische Detailangaben
1. Verfasser: Matthiesen, Svea (VerfasserIn)
Körperschaft: Universität Greifswald (Grad-verleihende Institution)
Weitere Verfasser: Knittler, Michael R. (AkademischeR BetreuerIn), Rödel, Jürgen (AkademischeR BetreuerIn), Daumke, Oliver (AkademischeR BetreuerIn)
Format: UnknownFormat
Sprache:ger
Veröffentlicht: Greifswald 18.01.2021
Schlagworte:
Hochschulschrift > Coxiella burneti > Q-Fieber > Dendritische Zelle > Killerzelle > Zelluläre Immunität > Immunologie
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Zusammenfassung:Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2021
Coxiella burnetii, Q-Fieber, Immunologie, Zellautonome Immunität
The causative agent of Q fever is the zoonotic intracellular bacterium Coxiella burnetii. C. burnetii is gram-negative and occurs in two different antigenic forms that differ in the structure of their lipopolysaccharide (LPS): a virulent Ph I LPS form, and an avirulent Ph II LPS form. Transmission to humans occurs through contact with infected animals or contaminated particulates, and causes an acute febrile infection that may progress to pneumonia or hepatitis. A small percentage of cases develop into chronic infections with bacterial persistence. C. burnetii infection induces both a humoral and cellular immune response. In addition to monocytes and macrophages, dendritic cells (DCs) serve as suitable host cells for infection. DCs belong to the first-line-of-defense of the innate immune system and make early contact with C. burnetii during infection, as do the natural killer (NK) cells that functionally cooperate with them. Antigen presentation by infected DCs also initiates the development of T cell immunity, which is critical for defense against C. burnetii, and functionally directs downstream immune responses. Despite this central role in immune function, the cellular processes taking place in DCs during C. burnetii infection, especially regarding cellular self-defense against Ph II LPS variants, are not sufficiently understood. This also holds true for the influence of NK cell produced IFN-γ and the role of the oxygen environment on cellular defense in infected APCs ...
Beschreibung:Literaturverzeichnis: Seite 178-206
Beschreibung:IV, 213 Seiten
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