Coiled coils as mechanical building blocks

Dissertation, Universität Potsdam, 2019

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Bibliographische Detailangaben
1. Verfasser:	López García, Patricia (VerfasserIn)
Körperschaft:	Universität Potsdam (Grad-verleihende Institution)
Weitere Verfasser:	Blank, Kerstin G. (AkademischeR BetreuerIn), Sullan, Ruby May Arana (AkademischeR BetreuerIn), Müller-Werkmeister, Henrike (AkademischeR BetreuerIn)
Format:	UnknownFormat
Sprache:	eng
Veröffentlicht:	Potsdam 2019
Schlagworte:	Hochschulschrift > Doppelhelix > Stabilität
Online Zugang:	Inhaltsverzeichnis
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Beschreibung
Zusammenfassung:	Dissertation, Universität Potsdam, 2019 The natural abundance of Coiled Coil (CC) motifs in cytoskeleton and extracellular matrix proteins suggests that CCs play an important role as passive (structural) and active (regulatory) mechanical building blocks. CCs are self-assembled superhelical structures consisting of 2-7 α-helices. Self-assembly is driven by hydrophobic and ionic interactions, while the helix propensity of the individual helices contributes additional stability to the structure. As a direct result of this simple sequence-structure relationship, CCs serve as templates for protein design and sequences with a pre-defined thermodynamic stability have been synthesized de novo. Despite this quickly increasing knowledge and the vast number of possible CC applications, the mechanical function of CCs has been largely overlooked and little is known about how different CC design parameters determine the mechanical stability of CCs. Once available, this knowledge will open up new applications for CCs as nanomechanical building blocks, e.g. in biomaterials and ...
Beschreibung:	xi, 130 Seiten Illustrationen, Diagramme