Functional analyses of porcine T-cell responses upon viral infections lessons learned from pigs as natural hosts and biomedical models
Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2021
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| Sprache: | eng |
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Greifswald
Dezember 2020
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Tag hinzufügen | Zusammenfassung: | Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2021 Afrikanische Schweinepest, Durchflusscytometrie, Immunologie, Influenzaviren, Sus scrofa domesticus, T-Lymphozyt, African swine fever virus, Biomedical model, Flow cytometry, Immunology, Influenza virus, Natural host, Pig, T cells Viral diseases are a threat to bacteria and enormous animals alike. Vaccines are available against several viruses. However, for some viruses, like ASFV, we still lack vaccines, while for others, like IAV, they are not as effective as we need them to be. To a large extent, this is because we do not fully understand the mechanisms conferring antiviral immunity. To improve our understanding of antiviral immunity, we used a model species that is in many immunological aspects closer to humans than the widely used laboratory mice, pigs. In this thesis, pigs were investigated as a potential biomedical model species for viral respiratory infections in humans and as a natural host for viral infections. Both approaches provide valuable insights into aspects of porcine immunology that can either be used as the foundation for translational research or for the design of targeted therapeutics and vaccines for pigs. Insights into fundamental characteristics of the porcine immune system form the basis for translational studies. Paper I pioneered a detailed characterization of porcine iNKT cells. To make pigs and porcine iNKT cells more available for scientific investigations, we established multicolor flow cytometry analysis platforms that allow for a more detailed investigation of these cells than previously possible. We found porcine iNKT cells circulating in peripheral blood to be a rare population among CD3+ lymphocytes that displays a pre-activated effector state and can be divided ... |
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| Beschreibung: | Literaturverzeichnis: Seite 164-181 |
| Beschreibung: | 187 Seiten Illustrationen (teilweise farbig), Diagramme (teilweise farbig) |