Der Einfluss des Immunsystems auf den Organschaden in der schweren akuten Pankreatitis und die Rolle von Interleukin 33 im Mausmodell

Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2021

Gespeichert in:
Bibliographische Detailangaben
1. Verfasser: Wilden, Anika (VerfasserIn)
Körperschaft: Universität Greifswald (Grad-verleihende Institution)
Weitere Verfasser: Lalk, Michael (AkademischeR BetreuerIn), Lerch, Markus M. (AkademischeR BetreuerIn), Jaster, Robert (AkademischeR BetreuerIn)
Format: UnknownFormat
Sprache:ger
Veröffentlicht: Greifswald 27.11.2020
Schlagworte:
Hochschulschrift > Akute Bauchspeicheldrüsenentzündung > Immunsystem > Organ > Krankheit > Interleukin 33 > Maus > Tiermodell
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2021
Immunsystem, Interleukin 33, Organschaden, schwere akute Pankreatitis
Acute pancreatitis is one of the most common non-malignant gastrointestinal diseases that leads to hospitalization. It is defined as the self-digestion of the pancreas by its own proteases like trypsin, elastase and chymotrypsin. The early intracellular activation of these digestive enzymes is considered to be the origin of the disease. This leads to cell death of the acinar cells and tissue damage. 20% of acute pancreatitis cases leads to severe course, that is associated with organ failure in the lungs and kidneys. It is known that an inflammatory reaction occurs and that a large amount of cytokines is released. White blood cells infiltrate the pancreas and increase tissue damage. DAMPs are released, which activate the innate and adaptive immune system. It is not well understood how the immune system influences the severe course of acute pancreatitis. There are few theories about organ damage in the lungs and kidneys. In this work, the focus was on organ damage in the lungs and kidneys and the effect of interleukin 33 (IL33) on the cells of the innate immune system and their migration into various organs during severe acute pancreatitis in the mouse model. The severe acute pancreatitis was induced by duct ligation and a single dose of caerulein on day 2 after duct ligation. On day 3 after induction, the mice were sacrificed and the organs were removed for further analysis. On the third day after the induction of pancreatitis, we observed organ damage in the lungs and ...
Beschreibung:Literaturverzeichnis: Seite 92-100
Beschreibung:XII, 102 Seiten
Illustrationen (farbig), Diagramme (teilweise farbig)