Zur Validität der Streifenmeniskometrie beim Syndrom des trockenen Auges

Dissertation, Universitätsmedizin der Universität Greifswald, 2020

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Bibliographische Detailangaben
1. Verfasser: Schulze, Konrad (VerfasserIn)
Körperschaft: Universität Greifswald (Grad-verleihende Institution)
Weitere Verfasser: Tost, Frank (AkademischeR BetreuerIn), Messmer, Elisabeth (AkademischeR BetreuerIn)
Format: UnknownFormat
Sprache:ger
Veröffentlicht: Greifswald 2019
Schlagworte:
Hochschulschrift > Keratokonjunktivitis sicca > Tränenflüssigkeit > Testen
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Zusammenfassung:Dissertation, Universitätsmedizin der Universität Greifswald, 2020
Trockenes Auge, Streifenmeniskometrie
Background: Strip meniscometry was tested for its suitability for the diagnosis of dry eye disease. It was also examined whether lid-parallel conjunctival folds (LIPCOF) or meibomian gland disease (MGD) have an influence on the measurement result. Material and Methodology: 391 eyes of 201 subjects (85 male, 116 female) aged 18 to 81 years (average age 53.17 ± 16.52 years) were assigned to 3 groups. 54 eyes with diagnosed Keratoconjunctivitis sicca (KCS) and 122 eyes with mild KCS were compared to 225 healthy eyes. Each eye was examined by strip meniscometry, Schirmer’s 1 test, the Jones test, optical coherence tomography (OCT) meniscometry (tear meniscus high - TMH, tear meniscus wide - TMW, tear meniscus area - TMA) and the Ocular Surface Disease Index (OSDI). Each eye was examined additionally for characteristic eyelid changes of MGD. The presence of LIPCOF was detected by OCT. Results: The results of strip meniscometry, Schirmer’s 1 test, the Jones test and OCT meniscometry (TMH, TMW and TMA) were significantly lower (p < .001) in the KCS subjects then in healthy subjects. The OSDI score in KCS subjects was significantly higher (p < .001). The result of strip meniscometry and the degree of KCS correlated with each other (r = -,396, p < .001). The sensitivity of strip meniscometry ranged from 0.79 to 0.89. However, the specificity in the range between 0.42 and 0.5 is unsatisfying. The strip meniscometry correlated with Schirmer’s 1 test, the Jones test and OCT meniscometry ...
Beschreibung:Literaturverzeichnis: Blatt 98-102
Beschreibung:107, IX Blätter
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