Camptothecin and camptothecin producing plants botany, chemistry, anticancer activity and biotechnology
Front Cover -- Camptothecin and Camptothecin Producing Plants -- Copyright Page -- Contents -- Preface -- Abbreviations -- 1 Cancer biology and other disorders: beneficial role of camptothecin and novel derivatives -- 1.1 Introduction -- 1.2 The principles underlying transformation of normal cells i...
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| Format: | UnknownFormat |
| Sprache: | eng |
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London, San Diego
Academic Press
2020
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| Online Zugang: | Inhaltsverzeichnis |
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Tag hinzufügen | Zusammenfassung: | Front Cover -- Camptothecin and Camptothecin Producing Plants -- Copyright Page -- Contents -- Preface -- Abbreviations -- 1 Cancer biology and other disorders: beneficial role of camptothecin and novel derivatives -- 1.1 Introduction -- 1.2 The principles underlying transformation of normal cells into tumor -- 1.2.1 Self-sufficiency in growth signals -- 1.2.2 Insensitivity to antigrowth signals -- 1.2.3 Evading apoptosis -- 1.2.4 Limitless Replicative potential -- 1.2.5 Sustained angiogenesis -- 1.2.6 Tissue invasion and metastasis -- 1.3 Nuclear transcription factor kappa B -- 1.3.1 Role of NF-κB in tumorigenesis -- 1.3.2 Nuclear factor of activated T cells -- 1.4 Programmed cell death-apoptosis -- 1.4.1 Molecular mechanisms of apoptosis -- 1.4.1.1 Extrinsic pathway of apoptosis -- 1.4.1.2 Intrinsic pathway of apoptosis -- 1.5 Targeted cancer therapy -- 1.5.1 Targeting apoptotic pathways in cancer cells -- 1.5.2 Transcription factors as targets for cancer therapy -- 1.5.3 Targeting NF-κB -- 1.5.3.1 Targeting nuclear factor of activated T cells -- 1.5.4 Targeting death receptors: FAS/CD95 receptor -- 1.6 Molecular mechanisms of drug resistance in cancer -- 1.6.1 Deregulation of the apoptotic machinery -- 1.6.1.1 Expression of antiapoptotic proteins -- 1.6.1.2 Inactivation of proapoptotic genes -- 1.6.2 Drug influx and efflux -- 1.6.3 Drug inactivation -- 1.6.4 Drug targets -- 1.6.5 Alterations of the p53 pathway -- 1.6.6 DNA damage repair -- 1.6.7 Alterations in the survival signaling -- 1.6.8 Cell cycle events in context to antitumor agents -- 1.7 Strategy to overcome chemoresistance -- 1.7.1 Combination therapy -- 1.8 Camptothecin -- 1.8.1 Camptothecin and related derivatives-biological activity -- 1.8.1.1 Antitumor activity -- 1.8.1.2 Antiviral activity -- 1.8.1.3 Pesticidal activity -- 1.8.1.4 Antiparasitic activity. |
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| Beschreibung: | xi, 353 Seiten Illustrationen, Diagramme |
| ISBN: | 9780128204993 978-0-12-820499-3 |