Membrane adhesion mediated via lipid-anchored saccharides
Dissertation, Universität Potsdam, 2019
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| Format: | UnknownFormat |
| Sprache: | eng |
| Veröffentlicht: |
Potsdam
2019
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| Schlagworte: |
Hochschulschrift
> Membran
> Adhäsion
> Chemische Bindung
> Rezeptor
> Ligand
> Lipide
> Kohlenhydrate
> Molekulardynamik
> Dimere
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Tag hinzufügen | Zusammenfassung: | Dissertation, Universität Potsdam, 2019 Membrane adhesion is a fundamental biological process in which membranes are attached to neighboring membranes or surfaces. Membrane adhesion emerges from a complex interplay between the binding of membrane-anchored receptors/ligands and the membrane properties. In this work, we study membrane adhesion mediated by lipid-anchored saccharides using microsecond-long full-atomistic molecular dynamics simulations. Motivated by neutron scattering experiments on membrane adhesion via lipid-anchored saccharides, we investigate the role of LeX, Lac1, and Lac2 saccharides and membrane fluctuations in membrane adhesion. We study the binding of saccharides in three different systems: for saccharides in water, for saccharides anchored to essentially planar membranes at fixed separations, and for saccharides anchored to apposing fluctuating membranes. Our simulations of two saccharides in water indicate that the saccharides engage in weak interactions to form dimers. ... |
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| Beschreibung: | 125 Seiten Illustrationen, Diagramme |