Biodegradable thermogels
Biodegradable thermogels are a promising class of stimuli-responsive polymers. This book summarizes recent developments in thermogel research with a focus on synthesis and self-assembly mechanisms, gel biodegradability, and applications for drug delivery, cell encapsulation and tissue engineering
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| Format: | UnknownFormat |
| Sprache: | eng |
| Veröffentlicht: |
Piccadilly, London
Royal Society of Chemistry
2019
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| Schriftenreihe: | Biomaterials science series
No. 2 |
| Schlagworte: | |
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Tag hinzufügen | Zusammenfassung: | Biodegradable thermogels are a promising class of stimuli-responsive polymers. This book summarizes recent developments in thermogel research with a focus on synthesis and self-assembly mechanisms, gel biodegradability, and applications for drug delivery, cell encapsulation and tissue engineering Cover -- Preface -- Contents -- Chapter 1 Thermogelling Polymers and Their History -- 1.1 Introduction -- 1.2 Synthesis -- 1.3 Micellization and Thermogelling Properties -- 1.3.1 Gelation Mechanism -- 1.3.2 Kinetics of Micellization -- 1.3.3 Formation of Micelles with Different Morphologies -- 1.4 Pluronic Systems in the Biomedical Sciences -- 1.4.1 Early Uses -- 1.4.2 Wound Healing -- 1.4.3 Drug Delivery -- 1.5 Disadvantages of Pluronic Systems -- 1.6 Modifications of Pluronic Copolymers -- 1.6.1 Modified Pluronic Copolymers for Improved Mechanical Properties -- 1.6.2 Modified Pluronic Copolymers for Improved Biodegradability -- 1.7 Modern Applications of Pluronics -- 1.8 Future Perspectives -- References -- Chapter 2 Thermogelling PLGA-based Copolymers -- 2.1 History and Structures -- 2.2 Synthesis -- 2.3 Properties -- 2.3.1 Reversible Sol-to-gel Transition -- 2.3.2 Degradation -- 2.3.3 Biocompatibility -- 2.4 Applications -- 2.4.1 Drug Release -- 2.4.2 Gene Delivery -- 2.4.3 Postoperative Adhesion Prevention -- 2.5 Areas for Future Research -- 2.6 Conclusions -- References -- Chapter 3 Polyester-based Biodegradable Thermogelling Systems as Emerging Materials for Therapeutic Applications -- 3.1 Introduction -- 3.2 Polyester-based Thermogelling Systems -- 3.2.1 The Poly(lactic acid)-based Thermogelling Systems -- 3.2.2 Polycaprolactone-based Thermogelling Systems -- 3.2.3 Poly([R]-3-hydroxybutyrate)-based Thermogelling System -- 3.2.4 Poly(glycerol sebacate)-based Thermogelling Systems -- 3.3 Application of Polyester-based Thermogelling Systems -- 3.3.1 Therapeutic Delivery -- 3.3.2 Tissue Engineering -- 3.4 Conclusion -- Abbreviations -- References -- Chapter 4 Biodegradable Thermogelling Polymers for Drug Delivery -- 4.1 Introduction -- 4.2 Thermogelling Mechanism -- 4.3 Mechanism of Drug Release in Thermogels 4.4 Advantages and Disadvantages of Thermogelling Polymeric Materials Compared to Other Drug-delivery Methods -- 4.5 Delivery of Insulin and Protein Drugs in the Treatment of Diabetes -- 4.6 Adaptation of Thermogels for Biomedical Applications -- 4.6.1 Selenium-containing Thermogels -- 4.6.2 Matrix Metalloproteinase-sensitive Thermogelling Polymers -- 4.7 Towards Understanding In-vivo Effectiveness of Polymeric Thermogel Drug Delivery -- 4.7.1 Toxicological Aspects of the Use of Dextran Microspheres and Thermogelling Ethyl(hydroxyethyl) Cellulose as Nasal Drug-delivery Systems -- 4.7.2 In-vivo Pharmacological Evaluations of an Antioxidant-loaded Biodegradable Thermogel -- 4.8 Conclusion -- References -- Chapter 5 Injectable Thermogelling Polymers for Bone and Cartilage Tissue Engineering -- 5.1 Introduction -- 5.2 Scaffold Requirements for Bone and Cartilage Tissue Engineering -- 5.3 Chemistry and Properties of Selected Injectable Thermogelling Scaffolds -- 5.3.1 Totally Non-degradable Polymers -- 5.3.2 Enzymatically Degradable Polymers -- 5.3.3 Hydrolytically Degradable Polymers -- 5.4 Conclusions -- References -- Chapter 6 Thermogels for Stem Cell Culture -- 6.1 Introduction -- 6.2 Thermogel 3D Scaffolds for Proliferation and Chondrogenic Differentiation of Stem Cells -- 6.3 3D Thermogel Scaffold for Proliferation and Osteogenic Differentiation of Stem Cells -- 6.4 Thermogel 3D Scaffold for Proliferation and Adipogenic Differentiation of Stem Cells -- 6.5 Conclusion -- References -- Chapter 7 Degradation Behaviour of Biodegradable Thermogels -- 7.1 Introduction -- 7.2 Relevance of Thermogels -- 7.2.1 Drug Delivery -- 7.2.2 Tissue Engineering -- 7.3 Importance of Degradability -- 7.4 Biodegradation -- 7.4.1 Surface Erosion -- 7.4.2 Bulk Erosion -- 7.4.3 Enzymatic Degradation -- 7.5 In Vivo Degradation -- 7.6 Factors Affecting the Degradation Rate 7.6.1 Material Properties -- 7.6.2 Packing of Micelles -- 7.6.3 Bond Type -- 7.6.4 Ratio of Hydrophilic to Hydrophobic Sections -- 7.6.5 Number of Sites for Enzymatic Action -- 7.7 Techniques to Study the Degradable Behaviour of Thermogels -- 7.7.1 Mass Loss -- 7.7.2 Molecular Weight Comparison -- 7.7.3 Surface Topography (Scanning Electron Microscopy) -- 7.7.4 Fourier-transform Infrared Spectroscopy -- 7.7.5 Nuclear Magnetic Resonance Spectroscopy -- 7.7.6 Technique Comparison -- 7.8 Future Perspective -- References -- Chapter 8 From Bench to Bedside - OncoGel™, an In Situ Hydrogel for In Vivo Applications -- 8.1 Introduction -- 8.2 Non-clinical Safety and Efficacy Evaluation -- 8.2.1 Safety Studies -- 8.2.2 Tissue Distribution Studies -- 8.3 Development of OncoGel™ as a Potential Cancer Therapeutic Drug -- 8.3.1 Rat Model Studies -- 8.3.2 Pig Model Studies -- 8.3.3 Human Clinical Trials -- 8.4 Perspective -- References -- Chapter 9 Hydrogel-based 3D Scaffolds for Stem Cell Culturing and Differentiation -- 9.1 Introduction -- 9.2 Hydrogel-based 3D Culturing and Differentiation of Stem Cells -- 9.3 Hydrogel-based 3D Scaffolds Induce Stem-cell-specific Differentiation -- 9.3.1 Scaffold-induced Neuronal Differentiation -- 9.3.2 Scaffold-induced Hepatogenic Differentiation -- 9.3.3 Scaffold Induced Chondrogenesis Differentiation -- 9.3.4 Scaffold-induced Osteogenic Differentiation -- 9.3.5 Scaffold-induced Adipogenic Differentiation -- 9.4 Conclusion -- References -- Chapter 10 Beyond Thermogels - Other Forms of Noncovalently Formed Polymeric Hydrogels -- 10.1 Introduction -- 10.2 Key Features of Noncovalent Polymeric Hydrogels -- 10.3 Types of Noncovalent Polymeric Hydrogels -- 10.3.1 Host-Guest-mediated Supramolecular Hydrogels -- 10.3.2 Noncovalent Hydrogels through Hydrophobic Association 10.3.3 Noncovalent Polymeric Hydrogels Through Forming Ionic Bonds -- 10.3.4 Dynamic Covalent Bond-based Polymeric Hydrogels -- 10.4 Summary and Outlook -- References -- Subject Index |
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| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xii, 186 Seiten Illustrationen, Diagramme 25 cm |
| ISBN: | 9781782629405 978-1-78262-940-5 1782629408 1-78262-940-8 |