DNA-targeting molecules as therapeutic agents
Chapter 1.DNA Recognition by Parallel Triplex Formation /Keith R. Fox, Tom Brown and David A. Rusling --Chapter 2.Interfacial Inhibitors /Evgeny Kiselev and Yves Pommier --Chapter 3.Slow DNA Binding /Per Lincoln, L. Marcus Wilhelmsson and Bengt Nordén --Chapter 4.Thermal denaturation of drug-DNA com...
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| Format: | UnknownFormat |
| Sprache: | eng |
| Veröffentlicht: |
Cambridge
Royal Society of Chemistry
2018
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| Schriftenreihe: | Chemical biology series
no. 7 |
| Schlagworte: | |
| Online Zugang: | Inhaltsverzeichnis |
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Tag hinzufügen | Zusammenfassung: | Chapter 1.DNA Recognition by Parallel Triplex Formation /Keith R. Fox, Tom Brown and David A. Rusling --Chapter 2.Interfacial Inhibitors /Evgeny Kiselev and Yves Pommier --Chapter 3.Slow DNA Binding /Per Lincoln, L. Marcus Wilhelmsson and Bengt Nordén --Chapter 4.Thermal denaturation of drug-DNA complexes /Jonathan B. Chaires --Chapter 5.Computer Simulations of Drug-DNA Interactions: A Personal Journey /Federico Gago --Chapter 6.Binding of Small Molecules to Trinucleotide DNA Repeats Associated with Neurodegenerative Diseases /Ming-Hon Hou, Roshan Satange and Chung-ke Chang --Chapter 7.Parsing the Enthalpy-Entropy Compensation Phenomenon of General DNA-Ligand Interactions by a 'Gradient Determinant' Approach /Robin C. K. Yang, Karen L. Kao, Wen-Chen Yao, Yu-Ling Chen, Chia-Chun Hung, Yu-Ting Li, Jia-Rong Wu, Wei-Kang Hung, Michael J. Waring and Leung Sheh --Chapter 8.Structural Studies of DNA-binding Metal Complexes of Therapeutic Importance /Christine J. Cardin and James P. Hall --Chapter 9.Therapeutic Potential of DNA Gene Targeting using Peptide Nucleic Acid (PNA) /Peter E. Nielsen --Chapter 10.Sequence-selective Interactions of Actinomycin D with DNA: Discovery of a Thermodynamic Switch /Jason S. Hudson, Aaron Lucius, Michael J. Waring and David E. Graves --Chapter 11.Molecular Modelling Approaches for Assessing Quadruplex-Small Molecule Interactions /Martyna Kuta, Barira Islam, Shozeb Haider and Stephen Neidle --Chapter 12.Molecular Recognition of DNA by Py-Im Polyamides: From Discovery to Oncology /Peter B. Dervan, Alexis A. Kurmis and Paul B. Finn --Chapter 13.Synthetic Peptides for DNA Recognition Inspired by Transcription Factors /Abhishek Iyer, Yara Ruiz Garcia and Annemieke Madder --Chapter 14.Targeting DNA Mismatches with Coordination Complexes /Jacqueline K. Barton, Adam N. Boynton and Kelsey M. Boyle --Chapter 15.CRISPR Highlights and Transition of Cas9 into a Genome Editing Tool /Thomas Bentin. This book explains key aspects of the progress that has been made towards understanding how drugs can bind specifically to nucleic acids, and thus underpin the endeavour to make gene targeting a reality. The binding of drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents and treats in depth topics such as DNA-binding metal complexes, peptide and polyamide-DNA interactions |
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| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xvii, 414 Seiten Illlustrationen; Diagramme 24 cm |
| ISBN: | 9781782629924 978-1-78262-992-4 1782629920 1-78262-992-0 |