Nuclear receptors in drug metabolism

Nuclear receptors in drug metabolism

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Bibliographische Detailangaben
Weitere Verfasser: Xie, Wen (HerausgeberIn)
Format: UnknownFormat
Sprache:eng
Veröffentlicht: Hoboken, NJ Wiley 2009
Schlagworte:
Receptors, Cytoplasmic and Nuclear / metabolism > Receptors, Steroid / metabolism > Pharmaceutical Preparations / metabolism > Drug Delivery Systems / methods > Drugs > Metabolism > Nuclear receptors (Biochemistry) > Genetic regulation
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Beschreibung
Beschreibung:Drug metabolism : significance and challenges -- Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors -- Nuclear receptor-mediated regulation of phase II conjugating enzymes -- Nuclear receptor-mediated regulation of drug transporters -- Structure and function of PXR and CAR -- Xenobiotic receptor cofactors and coregulators -- Animal models of xenobiotic nuclear receptors and their utility in drug development -- Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines -- Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics -- Beyond PXR and CAR, regulation of xenobiotic metabolism by other nuclear receptors -- Emerging role of retinoid-related orphan receptor (ROR) and its cross talk with LXR (liver X receptor) in the regulation of drug-metabolizing enzymes. - Includes bibliographical references and index. - Formerly CIP
Beschreibung:XXII, 330 S., [4] Bl. : Ill.
25cm
ISBN:0470086793
9780470086797