Untangling the double helix DNA entanglement and the action of the dna topoisomerases
An insuperable problem -- Nature's solutions: the DNA topoisomerases -- Breaking a DNA strand and holding onto -- The broken ends -- A magic swivel -- Moving one DNA double helix through another -- Real-time viewing of the DNA topoisomerases in action -- Manifestations of DNA entanglement: repl...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | UnknownFormat |
| Sprache: | eng |
| Veröffentlicht: |
Cold Spring Harbor, NY
Cold Spring Harbor Laboratory Press
2009
|
| Schlagworte: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Tag hinzufügen | Zusammenfassung: | An insuperable problem -- Nature's solutions: the DNA topoisomerases -- Breaking a DNA strand and holding onto -- The broken ends -- A magic swivel -- Moving one DNA double helix through another -- Real-time viewing of the DNA topoisomerases in action -- Manifestations of DNA entanglement: replication and recombination -- Manifestations of DNA entanglement: transcription and gene expression -- Beyond DNA untanglement: new twists on an old -- Theme -- From nature's battlefields to the clinical wards -- Appendix 1: identification of the covalent intermediates in topoisomerase-catalyzed reactions -- Appendix 2 catalysis of dna breakage and rejoining by dna topoisomerases. An insuperable problem -- Nature's solutions: the DNA topoisomerases -- Breaking a DNA strand and holding onto -- The broken ends -- A magic swivel -- Moving one DNA double helix through another -- Real-time viewing of the DNA topoisomerases in action -- Manifestations of DNA entanglement: replication and recombination -- Manifestations of DNA entanglement: transcription and gene expression -- Beyond DNA untanglement: new twists on an old -- Theme -- From nature's battlefields to the clinical wards -- Appendix 1: identification of the covalent intermediates in topoisomerase-catalyzed reactions -- Appendix 2 catalysis of dna breakage and rejoining by dna topoisomerases |
|---|---|
| Beschreibung: | XI, 233 S. Ill. |
| ISBN: | 9780879698638 978-0-87969-863-8 9780879698799 978-0-87969-879-9 |