Untersuchungen zum Einfluss von Bosentan und CA-074 Me auf Proliferation und Migration von Glioblastomzellen
Dissertation, Universitätsmedizin der Universität Greifswald, 2021
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Greifswald
2020
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Tag hinzufügen | Zusammenfassung: | Dissertation, Universitätsmedizin der Universität Greifswald, 2021 Bosentan, Glioblastoma multiforme, Pharmakologischer Antagonist Glioblastoma multiforme remains one of the most prognostically unfavorable human malignant neoplasms. A median survival of 15 months for patients suffering from glioblastoma multiforme following standard of care has not been substantially prolonged, despite considerable scientific effort being invested in multimodal therapeutic approaches. The high proliferation rate and the pronounced infiltrative growth as well as the lack of radio- and chemosensitivity of this tumor entity limit the therapeutic options to date. Against this background, the establishment of alternative therapeutic approaches is an urgent research task. In glioblastoma multiforme tissue, increased expression of components of the endothelin axis as well as the cysteine protease cathepsin B could be detected. In other malignant neoplasms such as colon, breast or prostate cancer, inhibition of these hormones/enzymes decreased proliferative and migratory activity of tumor cells with tissue-specific differences as well as ambivalences of inhibition results. In this dissertation, the expression behavior of the glioblastoma cell lines LN-18 and U 87 MG with regard to the above mentioned systems and the influence of dual blockade of endothelin receptors A and B by bosentan or selective inhibition of cathepsin B by CA-074 Me on cellular proliferation and migration were investigated under in vitro conditions. By quantitative RT-PCR, increased mRNA expression of both the endothelin axis and cathepsin B was detected in ... |
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| Beschreibung: | Literaturverzeichnis: Blatt 116-131 |
| Beschreibung: | vi, 136 Blätter Diagramme |