Post-vaccination molecular epidemiology of pneumococcal carriage among children less than five years of age in Cape Coast, Ghana

Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2020

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Bibliographische Detailangaben
1. Verfasser: Mills, Richael Odarko (VerfasserIn)
Körperschaft: Universität Greifswald (Grad-verleihende Institution)
Weitere Verfasser: Hammerschmidt, Sven (AkademischeR BetreuerIn), Flieger, Antje (AkademischeR BetreuerIn)
Format: UnknownFormat
Sprache:eng
Veröffentlicht: Greifswald 11.12.2020
Schlagworte:
Hochschulschrift > Ghana > Cape Coast > Streptococcus pneumoniae > Impfstoff > Immunisierung > Kind > Epidemiologie > Molekulare Diagnostik > Antibiotikum > Arzneimittelresistenz > Prävalenz > Serotyp > Sequenzanalyse
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Zusammenfassung:Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2020
Ghana, PCV13, antibiotic resistance, pneumococcal carriage, serotypes, virulence genes, Streptococcus pneumoniae
Streptococcus pneumoniae (the pneumococcus), a bacterium belonging to the normal flora in the human respiratory tract, continues to be an important pathogen due to its contribution to morbidity and mortality among children, the elderly, and immunocompromised persons. Global estimates of pneumococcal deaths among children declined by 51% between 2000 and 2015. This achievement was mainly due to the introduction of pneumococcal conjugate vaccines (PCVs) in countries with the highest pneumococcal burden. Since May 2012, children in Ghana have been receiving PCV vaccination as part of routine immunization. The continuous monitoring of the pneumococcus after PCV introduction is essential to understand the changing epidemiology of the pathogen in the population. This study therefore, aims to determine the (1) prevalence, serotypes, and sequence types of pneumococcal isolates, (2) antibiotic susceptibility patterns and the genetic basis for the antibiotic resistance among these pneumococcal isolates, and (3) prevalence of selected virulence genes that have been identified as potential vaccine candidates. Nasopharyngeal swabs were obtained from vaccinated children under five years of age in Cape Coast, Ghana. Six years after PCV implementation, we provide data on the epidemiology of pneumococcal strains circulating among children in Cape Coast Ghana. Standard microbiological and molecular techniques were used to identify and characterize the pneumococcal strains. Overall, ...
Beschreibung:Literaturverzeichnis: Seite 183-197
Beschreibung:vii, 226 Seiten
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