From single molecules to bulk materials tuning the viscoelastic properties of coiled coil cross-linked hydrogels
Dissertation, Universität Potsdam, 2020
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| Sprache: | eng |
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Potsdam
2020
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Tag hinzufügen | Zusammenfassung: | Dissertation, Universität Potsdam, 2020 The development of bioinspired self-assembling materials, such as hydrogels, with promising applications in cell culture, tissue engineering and drug delivery is a current focus in material science. Biogenic or bioinspired proteins and peptides are frequently used as versatile building blocks for extracellular matrix (ECM) mimicking hydrogels. However, precisely controlling and reversibly tuning the properties of these building blocks and the resulting hydrogels remains challenging. Precise control over the viscoelastic properties and self-healing abilities of hydrogels are key factors for developing intelligent materials to investigate cell matrix interactions. Thus, there is a need to develop building blocks that are self-healing, tunable and self-reporting. This thesis aims at the development of α-helical peptide building blocks, called coiled coils (CCs), which integrate these desired properties. Self-healing is a direct result of the fast self-assembly of these building blocks when used as material cross-links. Tunability is ... |
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| Beschreibung: | XVI, 140 Seiten Illustrationen, Diagramme |